The quality of the end product can be affected by the different topological forms of plasmid DNA. This makes reliable separation and quantification all the more important.

A new Technical Note shows how an optimised AEX method using the YMC Accura BioPro IEX QF can distinguish between key pDNA topologies across different plasmids and production batches.

Metal surfaces can interact with biomolecules, thereby affecting peak shape, sensitivity, and reproducibility.

Our new short video demonstrates the usefulness of bioinert column hardware and the difference it can make in practice.