Preparative LC scale-up calculator
Let our scale-up calculator assist you in scaling up the chromatographic parameters such as flow rate or the amount of packing material. The use of the calculator is very simple: You only have to fill in the fields with the corresponding values and, after the parameters have been scaled up, you can also select the appropriate YMC (semi)preparative columns on our overview page. Benefit from the expertise of our scale-up calculator.
Seamless Method Transfer with
the YMC Prep Scale-Up Calculator
Scaling up from analytical to preparative chromatography requires precision and control. The YMC Prep Scale-Up Calculator helps you adapt your method by calculating critical chromatographic parameters such as column volume, packing material quantity, flow rate, and adsorption time. This makes it easier to transfer methods from lab to production – saving time, reducing error, and supporting reproducible scale-up.
What is a Prep Scale-Up Calculator?
A prep scale-up calculator or chromatography column scale up calculator is a digital tool used to convert method parameters from analytical LC to preparative LC. Instead of guessing or manually recalculating, this scale up calculator uses key inputs from both your analytical and prep column setups – including column dimensions, particle size, and flow rate – to provide optimized prep conditions. The YMC Prep Scale-Up Calculator returns important values such as: Theoretical column volume, required packing material (g), flow rate for prep conditions, recommended adsorption time, scale-up factor. These values help ensure consistent separation quality as you move from small-scale development to larger production runs.
Benefits of the YMC Prep Scale-Up Calculator
Side-by-side input: Enter analytical and prep column parameters in parallel for direct comparison.
Instant calculation of scale-up values: Get results for column volume, flow rate, material usage, and more at a glance.
Accurate estimation of packing material and volume: Eliminate guesswork and improve resource planning.
Adsorption time alignment: Match retention behavior between column formats.
User-friendly interface: Simple, intuitive design made for chromatography professionals.
Why choose the YMC Prep Scale-Up Calculator?
The YMC Prep Scale-Up Calculator simplifies one of the most complex tasks in preparative chromatography: translating your analytical method to a larger scale. Instead of trial-and-error adjustments, this tool provides immediate, reliable values based on your exact column setup and flow conditions. It helps you save time, reduce waste, and minimize risk during method transfer. Developed with decades of expertise in liquid chromatography, this tool reflects YMC’s ongoing commitment to precision, reproducibility, and practical support for your workflows.
Discover More Calculators from YMC
YMC offers a complete suite of practical calculators to support chromatography workflows at every level:
Column Volume Calculator: Determine column bed volume in mL or L.
Flow Rate Calculator: Optimize flow rates for method consistency.
Packing Calculator: Calculate slurry volume and packing material requirements.
Residence Time Calculator: Determine retention time based on column and flow.
Discover all YMC calculators and enhance your chromatography workflows today!