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Use our Application Search to discover chromatography solutions for HPLC and UHPLC. Filter by industry, compound, or column type to find the ideal match for your analysis.
Advantages
YMC Size Exclusion Columns
High flexibility
Full scalability
Excellent reproducibility
High stability
Cost-efficiency
Precise molecular weight determination
No secondary interactions
Wide molecular weight range
CUSTOMER TESTIMONIALS
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About the Product
PRODUCT MEDIA
Engineered for
Molecular Clarity
Downloads
YMC SEC Columns Brochure
Download our detailed product brochure for in-depth insights into YMC Biochromatography columns or access the complete media package with extended materials.
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Applications
| Application | Column | Compound name | |
| Casein | YMC-Pack Diol-300 | Casein | |
| Chondroitin sulfate A | YMC-Pack Diol-300 | Chondroitin sulfate A, Na salt | |
| Chondroitin sulfate B | YMC-Pack Diol-300 | Chondroitin sulfate B, Na salt | |
| Chondroitin sulfate C | YMC-Pack Diol-300 | Chondroitin sulfate C, Na salt | |
| Chondroitin | YMC-Pack Diol-300 | Chondroitin, Na salt | |
| Cyclodextrins | YMC-Pack Diol-60 | γ-Cyclodextrin β-Cyclodextrin α-Cyclodextrin | |
| Cytochrome c | YMC-Pack Diol-120 | Cytochrome c (hexamer) Cytochrome c (tetramer) Cytochrome c (trimer) Cytochrome c (dimer) Cytochrome c (monomer) | |
| Glycine oligomers | YMC-Pack Diol-60 | Pentaglycine Triglycine Glycine | |
| Heparan sulfate | YMC-Pack Diol-300 | Heparan sulfate, Na salt | |
| Heparin | YMC-Pack Diol-300 | Heparin, Na salt | |
| Human IgG (λ), myeloma protein | YMC-Pack Diol-300 | Human IgG (λ), myeloma protein | |
| Human IgM (κ), myeloma protein | YMC-Pack Diol-300 | Normal human IgM (κ), myeloma protein | |
| Human immunoglobulins | YMC-Pack Diol-200 | Human IgM (κ), myeloma protein Normal human IgA Normal human IgG | |
| Hyaluronic acid | YMC-Pack Diol-300 | Hyaluronic acid, Na salt | |
| Keratan polysulfate | YMC-Pack Diol-300 | Keratan polysulfate, Na salt | |
| Keratan sulfate | YMC-Pack Diol-300 | Keratan sulfate, Na salt | |
| Maltooligosaccharides (G1 ～ G15) | YMC-Pack Diol-120 | Maltopentadecaose (G15) Maltotridecaose (G13) Maltoundecaose (G11) Maltoheptaose (G7) Maltopentaose (G5) Maltotriose (G3) Glucose (G1) | |
| Monoclonal antibody (MAb) | YMC-Pack Diol-200 | Mouse monoclonal IgG1 (anti-human IgG4) | |
| Nonionic surfactants | YMC-Pack Diol-120 | Triton X-100 | |
| Normal human IgA | YMC-Pack Diol-300 | Normal human IgA | |
| Normal human IgG | YMC-Pack Diol-300 | Normal human IgG | |
| Peptide fragments from myoglobin | YMC-Pack Diol-120 | myoglobin fragments 1-153 (MW 17000) 1-131 (MW 14500) 56-153 (MW 10700) 56-131 (MW 8200) 1-55 (MW 6300) 132-153 (MW 2500) | |
| Peptide mapping | YMC-Pack Diol-60 | Peptide mapping | |
| Peptides | YMC-Pack Diol-60 | Insulin (Bovine) Neurotensin Angiotensin II Glycine | |
| Plasma constituents | YMC-Pack Diol-200 | Human serumIgM IgA Fibrinogen γ-Globulin IgG Transferrin Albumin α1-Antitrypsin Carbonic anhydrase Lysozyme Uric acid Creatinine | |
| Plasmid pBR322 and pBR322 Hae III restriction fragments | YMC-Pack Diol-200 | Plasmid pBR322 (4361 bp) Plasmid pBR322 Hae III digest (8-587 bp) | |
| Plasmid pBR322 restriction fragments | YMC-Pack Diol-200 | Plasmid pBR322 cleaved with restriction endonuclease Msp I | |
| Polyethyleneglycols | YMC-Pack Diol-120 | PEG #20000 (MW 20000) PEG #6000 (MW 8400) PEG #4000 (MW 3350) PEG #1000 (MW 1000) PEG #300 (MW 300) Ethyleneglycol (MW 62) | |
| Proteins for molecular weight marker | YMC-Pack Diol-200 | Glutamate dehydrogenase (MW 290000) Lactate dehydrogenase (MW 142000) Enolase (MW 67000) Adenylate kinase (MW 32000) Cytochrome c (MW 12400) | |
| Proteins in human serum | YMC-Pack Diol-200 | IgG Transferrin Albumin | |
| Proteins in mouse ascites fluid | YMC-Pack Diol-200 | IgG Transferrin Albumin | |
| Pullulans | YMC-Pack Diol-300 | Pullulan P-800 (MW 853000) Pullulan P-50 (MW 48000) Pullulan P-20 (MW 23700) Pullulan P-5 (MW 5800) | |
| lgG, Fab and Fc fragments | YMC-Pack Diol-200 | Rabbit lgG Mouse lgG Fc fragment Mouse lgG Fab fragment |
Specifications
|
|
YMC-SEC MAB
|
YMC-Pack
Diol-60
|
YMC-Pack
Diol-120
|
YMC-Pack
Diol-200
|
YMC-Pack
Diol-300
|
|
Base material
|
silica
|
||||
|
Suitable for
|
antibodies, fragments, aggregates
|
peptides,
carbohydrates
|
intermediate
proteins
|
large proteins,
antibody fragments
|
very large proteins,
antibody aggregates
|
|
Rec. MW Range
|
10 - 700 kDa
|
<10 kDa
|
5 - 100 kDa
|
5 - 300 kDa
|
20 - 1,000 kDa
|
|
Pore Size [nm]
|
25
|
6
|
12
|
20
|
30
|
|
Particle Size [µm]
|
3
|
3, 5
|
3, 5
|
2, 3, 5
|
2, 3, 5
|
|
Rec. pH Range
|
|
5.0 - 7.5
|
|||
|
Max. Temp.
|
|
40°C
|
|||
Phase Details
YMC-SEC MAB
|
Modification (USP class)
|
Dihydroxypropyl (USP L20/L59)
|
|
Suitable for
|
antibodies, antibody fragments, antibody aggregates
|
|
Recommended MW range
|
10 - 700 kDa
|
|
Pore Size
|
25 nm / 250 Å
|
|
Particle Size
|
3 µm
|
|
Rec. pH Range
|
5.0 - 7.5
|
|
Max. Temp.
|
40°C
|
|
Pressure Limit
|
14 MPa / 2,030 psi
|
YMC-Pack Diol-60
|
Modification (USP class)
|
Dihydroxypropyl (USP L20)
|
|
Suitable for
|
peptides, carbohydrates
|
|
Recommended MW range
|
<10 kDa
|
|
Pore Size
|
6 nm / 60 Å
|
|
Particle Size
|
3 µm, 5 µm
|
|
Rec. pH Range
|
5.0 - 7.5
|
|
Max. Temp.
|
40°C
|
|
Pressure Limit
|
20 MPa / 3,000 psi
|
YMC-Pack Diol-120
|
Modification (USP class)
|
Dihydroxypropyl (USP L20/L59)
|
|
Suitable for
|
intermediate proteins
|
|
Recommended MW range
|
5 - 100 kDa
|
|
Pore Size
|
12 nm / 120 Å
|
|
Particle Size
|
3 µm, 5 µm
|
|
Rec. pH Range
|
5.0 - 7.5
|
|
Max. Temp.
|
40°C
|
|
Pressure Limit
|
20 MPa / 3,000 psi
|
YMC-Pack Diol-200
|
Modification (USP class)
|
Dihydroxypropyl (USP L20/L33/L59)
|
|
Suitable for
|
large proteins, antibody fragments
|
|
Recommended MW range
|
5 - 300 kDa
|
|
Pore Size
|
20 nm / 200 Å
|
|
Particle Size
|
2 µm, 3 µm, 5 µm
|
|
Rec. pH Range
|
5.0 - 7.5
|
|
Max. Temp.
|
40°C
|
|
Pressure Limit
|
2 µm: 45 MPa / 6,525 psi
3/5 µm: 20 MPa / 3,000 psi
|
YMC-Pack Diol-300
|
Modification (USP class)
|
Dihydroxypropyl (USP L20/L33/L59)
|
|
Suitable for
|
very large proteins, antibody aggregates
|
|
Recommended MW range
|
20 - 1,000 kDa
|
|
Pore Size
|
30 nm / 300 Å
|
|
Particle Size
|
2 µm, 3 µm, 5 µm
|
|
Rec. pH Range
|
5.0 - 7.5
|
|
Max. Temp.
|
40°C
|
|
Pressure Limit
|
2 µm: 45 MPa / 6,525 psi
3/5 µm: 20 MPa / 3,000 psi
|
Technical Library
| Title | Document Type | Language | Download |
 Analysis of Bevacizumab (Avastin®) by SEC-MALLS |
Application Note | EN | |
| Efficient separation and analysis of antibody fragments and their drug conjugates |
Application Note | EN | |
| Maximising the separation capacity in SEC by coupling two YMC-Pack Diol columns |
Application Note | EN | |
| Pore size selection for separation of oligonucleotides by YMC-Pack Diol columns |
Application Note | EN | |
| SEC Analysis of MAb Fragments with Increased Throughput and High Resolution |
Application Note | EN | |
| SEC separation of the ADC Brentuximab vedotin from its aggregates and fragments |
Application Note | EN | |
| SEC-Analysis of Bevacizumab (Avastin®) and its aggregates and fragments |
Application Note | EN | |
| Separation of siRNA and its single strands by SEC using YMC-Pack Diol-120 |
Application Note | EN | |
| YMC Application Collection - Antibodies & ADCs |
Application Note | EN | |
 YMC-Pack Diol SEC (HPLC/UHPLC) Care and Use |
Care and Use Instructions | EN | |
| YMC-SEC MAB Care and Use |
Care and Use Instructions | EN | |
 YMC Biochromatography Columns |
Catalogue | EN | |
| YMC Biochromatography Columns - SEC Columns Chapter |
Catalogue | EN | |
 How to calculate the molecular weight of nucleic acids |
Expert Tip | EN | |
 Analytical Stationary Phases for BioLC from YMC |
Overview | EN | |
| YMC Alternatives to Existing BioLC Columns |
Overview | EN | |
 The Principles of BioLC & YMC BioLC Phase Overview |
Poster | EN | |
| Use of Small Particle YMC SEC and IEX Materials for Improved Characterization of Monoclonal Antibodies |
Poster | EN | |
 YMC SEC columns and light scattering detection |
Technical Note | EN | |
 Grundlagen der Chromatographie für die Analyse und Aufreinigung von Biologika |
Whitepaper | DE |
Ordering Information
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- 2-3 days
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| Product | Description | Price | Stock |
| DL06S03-0104GC | YMC-Pack Diol-60, analytical guard cartridges (4.0 mm ID), 6 nm, S-3µm, 10 x 4.0 mm | - 629 CHF 513 € | |
| DL06S03-1546WT | YMC-Pack Diol-60, SEC column (4.6 mm ID), 6 nm, S-3 µm, 150 x 4.6 mm | - 1213 CHF 989 € | |
| DL06S03-2546WT | YMC-Pack Diol-60, SEC column (4.6 mm ID), 6 nm, S-3 µm, 250 x 4.6 mm | - 1352 CHF 1103 € | |
| DL06S03-3006WT | YMC-Pack Diol-60, SEC column (6.0 mm ID), 6 nm, S-3 µm, 300 x 6.0 mm | - 1676 CHF 1367 € | |
| DL06S03-3008WT | YMC-Pack Diol-60, SEC column (8.0 mm ID), 6 nm, S-3 µm, 300 x 8.0 mm | - 2052 CHF 1674 € | |
| DL06S03-3046WT | YMC-Pack Diol-60, SEC column (4.6 mm ID), 6 nm, S-3 µm, 300 x 4.6 mm | - 1514 CHF 1235 € | |
| DL06S05-0110CC | YMC-Pack Diol-60, semi-preparative guard cartridges (10 mm ID), 6 nm, S-5 µm, 10 x 10 mm | - 625 CHF 510 € | |
| DL06S05-0308WTG | YMC-Pack Diol-60, SEC guard column (8.0 mm ID), 6 nm, S-5 µm, 30 x 8.0 mm | - 1096 CHF 894 € | |
| DL06S05-0310WTG | YMC-Pack Diol-60, semi-preparative guard column (8.0 mm ID), 6 nm, S-5 µm, 30 x 10 mm | - 1096 CHF 894 € | |
| DL06S05-05Q1WT | YMC-Pack Diol-60, SEC column (2.1 mm ID), 6 nm, S-5 µm, 50 x 2.1 mm | - 980 CHF 799 € | |
| DL06S05-1546WT | YMC-Pack Diol-60, SEC column (4.6 mm ID), 6 nm, S-5 µm, 150 x 4.6 mm | - 1096 CHF 894 € | |
| DL06S05-2506WT | YMC-Pack Diol-60, SEC column (6.0 mm ID), 6 nm, S-5 µm, 250 x 6.0 mm | - 1412 CHF 1152 € | |
| DL06S05-2510WT | YMC-Pack Diol-60, semi-preparative SEC column (10 mm ID), 6 nm, S-5 µm, 250 x 10 mm | - 2011 CHF 1640 € | |
| DL06S05-2520WT | YMC-Pack Diol-60, semi-preparative SEC column (20 mm ID), 6 nm, S-5 µm, 250 x 20 mm | - 6173 CHF 5035 € | |
| DL06S05-2530WT | YMC-Pack Diol-60, semi-preparative SEC column (30 mm ID), 6 nm, S-5 µm, 250 x 30 mm | - 17261 CHF 14079 € | |
| DL06S05-2546WT | YMC-Pack Diol-60, SEC column (4.6 mm ID), 6 nm, S-5 µm, 250 x 4.6 mm | - 1255 CHF 1024 € | |
| DL06S05-3006WT | YMC-Pack Diol-60, SEC column (6.0 mm ID), 6 nm, S-5 µm, 300 x 6.0 mm | - 1514 CHF 1235 € | |
| DL06S05-3008WT | YMC-Pack Diol-60, SEC column (8.0 mm ID), 6 nm, S-5 µm, 300 x 8.0 mm | - 1870 CHF 1525 € | |
| DL06S05-3020WT | YMC-Pack Diol-60, semi-preparative SEC column (20 mm ID), 6 nm, S-5 µm, 300 x 20 mm | - 6536 CHF 5331 € | |
| DL06S05-3046WT | YMC-Pack Diol-60, SEC column (4.6 mm ID), 6 nm, S-5 µm, 300 x 4.6 mm | - 1352 CHF 1103 € | |
| DL06S05-5006WT | YMC-Pack Diol-60, SEC column (6.0 mm ID), 6 nm, S-5 µm, 500 x 6.0 mm | - 3029 CHF 2471 € | |
| DL06S05-5008WT | YMC-Pack Diol-60, SEC column (8.0 mm ID), 6 nm, S-5 µm, 500 x 8.0 mm | - 3108 CHF 2535 € | |
| DL06S05-5020WT | YMC-Pack Diol-60, semi-preparative SEC column (20 mm ID), 6 nm, S-5 µm, 500 x 20 mm | - 10659 CHF 8694 € | |
| DL12S03-0104GC | YMC-Pack Diol-120, analytical guard cartridges (4.0 mm ID), 12 nm, S-3µm, 10 x 4.0 mm | - 629 CHF 513 € | |
| DL12S03-0308WTG | YMC-Pack Diol-120, SEC guard column (8.0 mm ID), 12 nm, S-3 µm, 30 x 8.0 mm | - 1096 CHF 894 € | |
| DL12S03-0546WT | YMC-Pack Diol-120, SEC column (4.6 mm ID), 12 nm, S-3 µm, 50 x 4.6 mm | - 1069 CHF 872 € | |
| DL12S03-1546WT | YMC-Pack Diol-120, SEC column (4.6 mm ID), 12 nm, S-3 µm, 150 x 4.6 mm | - 1213 CHF 989 € | |
| DL12S03-2546WT | YMC-Pack Diol-120, SEC column (4.6 mm ID), 12 nm, S-3 µm, 250 x 4.6 mm | - 1352 CHF 1103 € | |
| DL12S03-3006WT | YMC-Pack Diol-120, SEC column (6.0 mm ID), 12 nm, S-3 µm, 300 x 6.0 mm | - 1676 CHF 1367 € | |
| DL12S03-3008WT | YMC-Pack Diol-120, SEC column (8.0 mm ID), 12 nm, S-3 µm, 300 x 8.0 mm | - 2052 CHF 1674 € | |
| DL12S03-3046WT | YMC-Pack Diol-120, SEC column (4.6 mm ID), 12 nm, S-3 µm, 300 x 4.6 mm | - 1514 CHF 1235 € | |
| DL12S05-0104GC | YMC-Pack Diol-120, analytical guard cartridges (4.0 mm ID), 12 nm, S-5µm, 10 x 4.0 mm | - 629 CHF 513 € | |
| DL12S05-0110CC | YMC-Pack Diol-120, semi-preparative guard cartridges (10 mm ID), 12 nm, S-5µm, 10 x 10 mm | - 644 CHF 525 € | |
| DL12S05-0120CCN | YMC-Pack Diol-120, semi-preparative guard cartridges (20 mm ID), 12 nm, S-5µm, 10 x 20 mm | - 959 CHF 782 € | |
| DL12S05-01Q1GC | YMC-Pack Diol-120, analytical guard cartridges (2.1 mm ID), 12 nm, S-5µm, 10 x 2.1 mm | - 629 CHF 513 € | |
| DL12S05-0308WTG | YMC-Pack Diol-120, SEC guard column (8.0 mm ID), 12 nm, S-5 µm, 30 x 8.0 mm | - 1096 CHF 894 € | |
| DL12S05-0310WTG | YMC-Pack Diol-120, semi-preparative guard column (8.0 mm ID), 12 nm, S-5 µm, 30 x 10 mm | - 1096 CHF 894 € | |
| DL12S05-05Q1WT | YMC-Pack Diol-120, analytical SEC column (2.1 mm ID), 12 nm, S-5µm, 50 x 2.1 mm | - 980 CHF 799 € | |
| DL12S05-10Q1WT | YMC-Pack Diol-120, analytical SEC column (2.1 mm ID), 12 nm, S-5µm, 100 x 2.1 mm | - 997 CHF 813 € | |
| DL12S05-1510PTC | YMC Accura Diol-120, bioinert coated semi-preparative SEC column (10 mm ID), 12 nm, S-5 µm, 150 x 10 mm | - 2837 CHF 2314 € | |
| DL12S05-1520WT | YMC-Pack Diol-120, semi-preparative SEC column (20 mm ID), 12 nm, S-5 µm, 150 x 20 mm | - 4951 CHF 4038 € | |
| DL12S05-1546WT | YMC-Pack Diol-120, analytical SEC column (4.6 mm ID), 12 nm, S-5µm, 150 x 4.6 mm | - 1096 CHF 894 € | |
| DL12S05-2504WT | YMC-Pack Diol-120, analytical SEC column (4.0 mm ID), 12 nm, S-5µm, 250 x 4.0 mm | - 1255 CHF 1024 € | |
| DL12S05-2506WT | YMC-Pack Diol-120, SEC column (6.0 mm ID), 12 nm, S-5 µm, 250 x 6.0 mm | - 1412 CHF 1152 € | |
| DL12S05-2510WT | YMC-Pack Diol-120, semi-preparative SEC column (10 mm ID), 12 nm, S-5 µm, 250 x 10 mm | - 2011 CHF 1640 € | |
| DL12S05-2520WT | YMC-Pack Diol-120, semi-preparative SEC column (20 mm ID), 12 nm, S-5 µm, 250 x 20 mm | - 6173 CHF 5035 € | |
| DL12S05-2530WT | YMC-Pack Diol-120, semi-preparative SEC column (30 mm ID), 12 nm, S-5 µm, 250 x 30 mm | - 17261 CHF 14079 € | |
| DL12S05-2546WT | YMC-Pack Diol-120, SEC column (4.6 mm ID), 12 nm, S-5 µm, 250 x 4.6 mm | - 1255 CHF 1024 € | |
| DL12S05-3006WT | YMC-Pack Diol-120, SEC column (6.0 mm ID), 12 nm, S-5 µm, 300 x 6.0 mm | - 1514 CHF 1235 € | |
| DL12S05-3008WT | YMC-Pack Diol-120, SEC column (8.0 mm ID), 12 nm, S-5 µm, 300 x 8.0 mm | - 1870 CHF 1525 € | |
| DL12S05-3010PTC | YMC Accura Diol-120, bioinert coated semi-preparative SEC column (10 mm ID), 12 nm, S-5 µm, 300 x 10 mm | - 3535 CHF 2883 € | |
| DL12S05-3020WT | YMC-Pack Diol-120, semi-preparative SEC column (20 mm ID), 12 nm, S-5 µm, 300 x 20 mm | - 6536 CHF 5331 € | |
| DL12S05-3046WT | YMC-Pack Diol-120, SEC column (4.6 mm ID), 12 nm, S-5 µm, 300 x 4.6 mm | - 1352 CHF 1103 € | |
| DL12S05-5006WT | YMC-Pack Diol-120, SEC column (6.0 mm ID), 12 nm, S-5 µm, 500 x 6.0 mm | - 3029 CHF 2471 € | |
| DL12S05-5008WT | YMC-Pack Diol-120, SEC column (8.0 mm ID), 12 nm, S-5 µm, 500 x 8.0 mm | - 3108 CHF 2535 € | |
| DL20S02-0104GC | YMC-Pack Diol-200 UHPLC, analytical guard cartridges (4.0 mm ID), 20 nm, S-2µm, 10 x 4.0 mm | - 1063 CHF 867 € | |
| DL20S02-0204GC | YMC-Pack Diol-200 UHPLC, analytical guard cartridges (4.0 mm ID), 20 nm, S-2µm, 20 x 4.0 mm | - 1645 CHF 1342 € | |
| DL20S02-1546PTH | YMC-Pack Diol-200 UHPLC, SEC column (4.6 mm ID), 20 nm, S-2 µm, 150 x 4.6 mm | - 2618 CHF 2135 € | |
| DL20S02-3046PTH | YMC-Pack Diol-200 UHPLC, SEC column (4.6 mm ID), 20 nm, S-2 µm, 300 x 4.6 mm | - 3525 CHF 2875 € | |
| DL20S03-0104GC | YMC-Pack Diol-200, analytical guard cartridges (4.0 mm ID), 20 nm, S-3µm, 10 x 4.0 mm | - 629 CHF 513 € | |
| DL20S03-0308WTG | YMC-Pack Diol-200, SEC guard column (8.0 mm ID), 20 nm, S-3 µm, 30 x 8.0 mm | - 1096 CHF 894 € | |
| DL20S03-0546WT | YMC-Pack Diol-200, SEC column (4.6 mm ID), 20 nm, S-3 µm, 50 x 4.6 mm | - 1011 CHF 825 € | |
| DL20S03-1508WT | YMC-Pack Diol-200, SEC column (8.0 mm ID), 20 nm, S-3 µm, 150 x 8.0 mm | - 1692 CHF 1380 € | |
| DL20S03-1546WT | YMC-Pack Diol-200, SEC column (4.6 mm ID), 20 nm, S-3 µm, 150 x 4.6 mm | - 1213 CHF 989 € | |
| DL20S03-2546WT | YMC-Pack Diol-200, SEC column (4.6 mm ID), 20 nm, S-3 µm, 250 x 4.6 mm | - 1352 CHF 1103 € | |
| DL20S03-3006WT | YMC-Pack Diol-200, SEC column (6.0 mm ID), 20 nm, S-3 µm, 300 x 6.0 mm | - 1676 CHF 1367 € | |
| DL20S03-3008WT | YMC-Pack Diol-200, SEC column (8.0 mm ID), 20 nm, S-3 µm, 300 x 8.0 mm | - 2052 CHF 1674 € | |
| DL20S03-3046WT | YMC-Pack Diol-200, SEC column (4.6 mm ID), 20 nm, S-3 µm, 300 x 4.6 mm | - 1514 CHF 1235 € | |
| DL20S05-0104GC | YMC-Pack Diol-200, analytical guard cartridges (4.0 mm ID), 20 nm, S-5µm, 10 x 4.0 mm | - 629 CHF 513 € | |
| DL20S05-0105WFG | YMC-Pack Diol-200, guard column (5.0 mm ID), 12 nm, S-5 µm, 10 x 5.0 mm (1pc.) | - 702 CHF 573 € | |
| DL20S05-0110CC | YMC-Pack Diol-200, semi-preparative guard cartridges (10 mm ID), 20 nm, S-5µm, 10 x 10 mm | - 644 CHF 525 € | |
| DL20S05-0120CCN | YMC-Pack Diol-200, semi-preparative guard cartridges (20 mm ID), 20 nm, S-5µm, 10 x 20 mm | - 959 CHF 782 € | |
| DL20S05-0308WTG | YMC-Pack Diol-200, SEC guard column ((8.0 mm ID)), 20 nm, S-5 µm, 30 x 8.0 mm | - 1029 CHF 839 € | |
| DL20S05-1002WT | YMC-Pack Diol-200, analytical SEC column (2.0 mm ID), 20 nm, S-5µm, 100 x 2.0 mm | - 931 CHF 759 € | |
| DL20S05-1508WT | YMC-Pack Diol-200, SEC column (8.0 mm ID), 20 nm, S-5 µm, 150 x 8.0 mm | - 1365 CHF 1113 € | |
| DL20S05-2506WT | YMC-Pack Diol-200, SEC column (6.0 mm ID), 20 nm, S-5 µm, 250 x 6.0 mm | - 1327 CHF 1082 € | |
| DL20S05-2510WT | YMC-Pack Diol-200, semi-preparative SEC column (10 mm ID), 20 nm, S-5 µm, 250 x 10 mm | - 1888 CHF 1540 € | |
| DL20S05-2520WT | YMC-Pack Diol-200, semi-preparative SEC column (20 mm ID), 20 nm, S-5 µm, 250 x 20 mm | - 5797 CHF 4728 € | |
| DL20S05-2530WT | YMC-Pack Diol-200, semi-preparative SEC column (30 mm ID), 20 nm, S-5 µm, 250 x 30 mm | - 16206 CHF 13219 € | |
| DL20S05-2546WT | YMC-Pack Diol-200, SEC column (4.6 mm ID), 20 nm, S-5 µm, 250 x 4.6 mm | - 1179 CHF 962 € | |
| DL20S05-3006WT | YMC-Pack Diol-200, SEC column (6.0 mm ID), 20 nm, S-5 µm, 300 x 6.0 mm | - 1422 CHF 1160 € | |
| DL20S05-3008WT | YMC-Pack Diol-200, SEC column (8.0 mm ID), 20 nm, S-5 µm, 300 x 8.0 mm | - 1756 CHF 1432 € | |
| DL20S05-3046WT | YMC-Pack Diol-200, SEC column (4.6 mm ID), 20 nm, S-5 µm, 300 x 4.6 mm | - 1270 CHF 1036 € | |
| DL20S05-5006WT | YMC-Pack Diol-200, SEC column (6.0 mm ID), 20 nm, S-5 µm, 500 x 6.0 mm | - 2844 CHF 2320 € | |
| DL20S05-5008WT | YMC-Pack Diol-200, SEC column (8.0 mm ID), 20 nm, S-5 µm, 500 x 8.0 mm | - 2919 CHF 2381 € | |
| DL30S02-0104GC | YMC-Pack Diol-300 UHPLC, analytical guard cartridges (4.0 mm ID), 30 nm, S-2µm, 10 x 4.0 mm | - 1040 CHF 848 € | |
| DL30S02-1546PTH | YMC-Pack Diol-300 UHPLC, SEC column (4.6 mm ID), 30 nm, S-2 µm, 150 x 4.6 mm | - 2618 CHF 2135 € | |
| DL30S02-15H0AU | YMC-Pack Diol-300 UHPLC, capillary column 1/16", 30 nm, S-2 µm, 150 x 0.3 mm | - 1296 CHF 1057 € | |
| DL30S02-3046PTH | YMC-Pack Diol-300 UHPLC, SEC column (4.6 mm ID), 30 nm, S-2 µm, 300 x 4.6 mm | - 3525 CHF 2875 € | |
| DL30S03-0104GC | YMC-Pack Diol-300, analytical guard cartridges (4.0 mm ID), 30 nm, S-3µm, 10 x 4.0 mm | - 629 CHF 513 € | |
| DL30S03-0308WTG | YMC-Pack Diol-300, SEC guard column (8.0 mm ID), 30 nm, S-3 µm, 30 x 8.0 mm | - 1096 CHF 894 € | |
| DL30S03-1508WT | YMC-Pack Diol-300, SEC column (8.0 mm ID), 30 nm, S-3 µm, 150 x 8.0 mm | - 1692 CHF 1380 € | |
| DL30S03-1546WT | YMC-Pack Diol-300, SEC column (4.6 mm ID), 30 nm, S-3 µm, 150 x 4.6 mm | - 1213 CHF 989 € | |
| DL30S03-2546WT | YMC-Pack Diol-300, SEC column (4.6 mm ID), 30 nm, S-3 µm, 250 x 4.6 mm | - 1352 CHF 1103 € | |
| DL30S03-3006WT | YMC-Pack Diol-300, SEC column (6.0 mm ID), 30 nm, S-3 µm, 300 x 6.0 mm | - 1676 CHF 1367 € | |
| DL30S03-3008WT | YMC-Pack Diol-300, SEC column (8.0 mm ID), 30 nm, S-3 µm, 300 x 8.0 mm | - 2052 CHF 1674 € | |
| DL30S03-3046WT | YMC-Pack Diol-300, SEC column (4.6 mm ID), 30 nm, S-3 µm, 300 x 4.6 mm | - 1514 CHF 1235 € | |
| DL30S05-0104GC | YMC-Pack Diol-300, analytical guard cartridges (4.0 mm ID), 30 nm, S-5µm, 10 x 4.0 mm | - 629 CHF 513 € | |
| DL30S05-0105WFG | YMC-Pack Diol-300, SEC guard columns (5.0 mm ID), 30 nm, S-5 µm, 10 x 5.0 mm (1pc.) | - 706 CHF 576 € | |
| DL30S05-0110CC | YMC-Pack Diol-300, semi-preparative guard cartridges (10 mm ID),30 nm, S-5µm, 10 x 10 mm | - 644 CHF 525 € | |
| DL30S05-0120CCN | YMC-Pack Diol-300, semi-preparative guard cartridges (20 mm ID), 30 nm, S-5µm, 10 x 20 mm | - 959 CHF 782 € | |
| DL30S05-0204GC | YMC-Pack Diol-300, analytical guard cartridges (4.0 mm ID), 30 nm, S-5µm, 20 x 4.0 mm | - 721 CHF 588 € | |
| DL30S05-0308WTG | YMC-Pack Diol-300, SEC guard column (8.0 mm ID), 30 nm, S-5 µm, 30 x 8.0 mm | - 918 CHF 749 € | |
| DL30S05-0310WTG | YMC-Pack Diol-300, semi-preparative guard column (10 mm ID), 30 nm, S-5 µm, 30 x 10 mm | - 1029 CHF 839 € | |
| DL30S05-1503WT | YMC-Pack Diol-300, analytical SEC column (3.0 mm ID)), 30 nm, S-5µm, 150 x 3.0 mm | - 918 CHF 749 € | |
| DL30S05-1508WT | YMC-Pack Diol-300, SEC column (8.0 mm ID), 30 nm, S-3 µm, 150 x 8.0 mm | - 1365 CHF 1113 € | |
| DL30S05-1520WT | YMC-Pack Diol-300, semi-preparative SEC column (20 mm ID), 30 nm, S-5 µm, 150 x 20 mm | - 4649 CHF 3792 € | |
| DL30S05-1546WT | YMC-Pack Diol-300, SEC column (4.6 mm ID), 30 nm, S-5 µm, 150 x 4.6 mm | - 1029 CHF 839 € | |
| DL30S05-2506WT | YMC-Pack Diol-300, SEC column (6.0 mm ID), 30 nm, S-5 µm, 250 x 6.0 mm | - 1327 CHF 1082 € | |
| DL30S05-2510WT | YMC-Pack Diol-300, semi-preparative SEC column (10 mm ID), 30 nm, S-5 µm, 250 x 10 mm | - 1888 CHF 1540 € | |
| DL30S05-2520WT | YMC-Pack Diol-300, semi-preparative SEC column (20 mm ID), 30 nm, S-5 µm, 250 x 20 mm | - 5797 CHF 4728 € | |
| DL30S05-2530WT | YMC-Pack Diol-300, semi-preparative SEC column (30 mm ID), 30 nm, S-5 µm, 250 x 30 mm | - 16206 CHF 13219 € | |
| DL30S05-2546WT | YMC-Pack Diol-300, SEC column (4.6 mm ID), 30 nm, S-5 µm, 250 x 4.6 mm | - 1179 CHF 962 € | |
| DL30S05-3006WT | YMC-Pack Diol-300, SEC column (6.0 mm ID), 30 nm, S-5 µm, 300 x 6.0 mm | - 1422 CHF 1160 € | |
| DL30S05-3008WT | YMC-Pack Diol-300, SEC column (8.0 mm ID), 30 nm, S-5 µm, 300 x 8.0 mm | - 1756 CHF 1432 € | |
| DL30S05-3020WT | YMC-Pack Diol-300, semi-preparative SEC column (20 mm ID), 30 nm, S-5 µm, 300 x 20 mm | - 6137 CHF 5006 € | |
| DL30S05-3046WT | YMC-Pack Diol-300, SEC column (4.6 mm ID), 30 nm, S-5 µm, 300 x 4.6 mm | - 1270 CHF 1036 € | |
| DL30S05-5006WT | YMC-Pack Diol-300, SEC column (6.0 mm ID), 30 nm, S-5 µm, 500 x 6.0 mm | - 2844 CHF 2320 € | |
| DL30S05-5008WT | YMC-Pack Diol-300, SEC column (8.0 mm ID), 30 nm, S-5 µm, 500 x 8.0 mm | - 2919 CHF 2381 € | |
| DLM25S03-0104GC | YMC-SEC MAB, analytical guard cartridges (4.0 mm ID), 25 nm, S-3µm, 10 x 4.0 mm | - 629 CHF 513 € | |
| DLM25S03-0308WTG | YMC-SEC MAB, SEC guard column (8.0 mm ID), 25 nm, S-3 µm, 30 x 8.0 mm | - 1268 CHF 1034 € | |
| DLM25S03-15H0AU | YMC-SEC MAB, capillary column 1/16", 25 nm, S-3 µm, 150 x 0.3 mm | - 1273 CHF 1038 € | |
| DLM25S03-15H0RU | YMC-SEC MAB, capillary column 1/32", 25 nm, S-3 µm, 150 x 0.3 mm | - 1273 CHF 1038 € | |
| DLM25S03-15J0AU | YMC-SEC MAB, capillary column 1/16", 25 nm, S-3 µm, 150 x 0.5 mm | - 1273 CHF 1038 € | |
| DLM25S03-25H0AU | YMC-SEC MAB, capillary column 1/16", 25 nm, S-3 µm, 250 x 0.3 mm | - 1273 CHF 1038 € | |
| DLM25S03-25J0AU | YMC-SEC MAB, capillary column 1/16", 25 nm, S-3 µm, 250 x 0.5 mm | - 1273 CHF 1038 € | |
| DLM25S03-3008WT | YMC-SEC MAB, SEC column (8.0 mm ID), 25 nm, S-3 µm, 300 x 8.0 mm | - 4707 CHF 3839 € | |
| DLM25S03-3046WT | YMC-SEC MAB, SEC column (4.6 mm ID), 25 nm, S-3 µm, 300 x 4.6 mm | - 3147 CHF 2567 € | |
| DLM25S03-30J0AU | YMC-SEC MAB, capillary column 1/16", 25 nm, S-3 µm, 300 x 0.5 mm | - 1273 CHF 1038 € | |
| XRPRCP02 | Precolumn filter 2 µm for 1/16" OD + holder, PEEK (350 bar) | - 370 CHF 302 € | |
| XRPRCP25 | Replacement precolumn filter 2 µm for 1/16" OD, PEEK (350 bar) | - 271 CHF 221 € |
Guide to Size Exclusion Chromatography (SEC) for HPLC & UHPLC
What Are SEC Columns?
Size Exclusion Chromatography (SEC), also known as gel filtration chromatography, is a widely used method in HPLC & UHPLC for the separation of biomolecules based on their molecular size. Unlike other chromatographic techniques, SEC does not depend on chemical interactions between the analyte and the stationary phase. Instead, separation occurs through a porous stationary phase, where molecules are sorted according to their hydrodynamic volume. This approach ensures gentle and highly reproducible separations, making SEC ideal for applications such as protein and peptide analysis, oligonucleotide characterization, and the detection of monoclonal antibody (mAb) aggregates.
How Do SEC Columns Work?
The separation process in SEC is based on molecular exclusion, meaning that smaller molecules enter the pores of the stationary phase and are retained longer, whereas larger molecules are excluded from the pores and elute faster. This mechanism allows for precise separation without unwanted secondary interactions. The method is widely used in biopharmaceutical research, protein purification, and quality control, where accurate molecular weight determination is critical.
Choosing the Right SEC Column for Your Application
YMC offers a selection of SEC columns tailored to different bioanalytical needs:
- YMC-Pack Diol SEC columns: Designed for a broad range of biomolecules, from small peptides to large proteins, with multiple pore sizes available (60, 120, 200, and 300 Å) to optimize separation efficiency.
- YMC-SEC MAB columns: Specifically developed for the analysis of monoclonal antibodies (mAbs), providing exceptional resolution across both high and low molecular weight ranges, making them particularly effective for aggregate and fragment detection.
- Multiple column dimensions: Supporting both analytical and preparative scale separations, ensuring maximum flexibility for various SEC chromatography workflows.
Applications of SEC Chromatography in HPLC & UHPLC
ISEC is an essential technique in many bioanalytical workflows, particularly in biopharmaceutical research, where it is used for protein characterization, biosimilar development, and vaccine analysis. It is also widely applied in protein purification and quality control, ensuring batch-to-batch consistency in biotherapeutic formulations. Another key application is aggregation studies, where SEC enables the reliable detection and quantification of protein aggregates, ensuring the stability and efficacy of pharmaceutical products.
For expert advice on selecting the optimal SEC column for your analytical needs, contact YMC Europe today.