Advantages
- For RP, NP an SFC applications
- Multiple chiral selectors available
- High loadability
- Screening kits available
- Free chiral screening service
Available Stationary Phases:
Coated type
Immobilised type
| CHIRAL ART Amylose-C Neo | CHIRAL ART Cellulose-C | |
| Chiral Selector | Amylose tris (3,5-dimethylphenyl- carbamate) | Cellulose tris (3,5-dimethylphenyl- carbamate) |
| Type | coated | |
| Particle Size [µm] | 10 | |
| Separation Mode | NP / SFC / SMB | |
| pH Range | 3.5 - 6.5 | |
| CHIRAL ART Amylose-SA | CHIRAL ART Cellulose-SB | CHIRAL ART Cellulose-SC | CHIRAL ART Cellulose-SJ | |
| Chiral Selector | Amylose tris (3,5-dimethylphenyl- carbamate) | Cellulose tris (3,5-dimethylphenyl- carbamate) | Cellulose tris (3,5-dichlorophenyl- carbamate) | Cellulose tris (4-methylbenzoat) |
| Type | immobilised | |||
| Particle Size [µm] | 10 | |||
| Separation Mode | RP / NP / SFC / SMB | |||
| pH Range | 2.0 - 9.0 | |||
For the separation of propanolol, loading studies in analytical scale have been performed using YMC's CHIRAL ART Cellulose-SB and a competitors chiral stationary phase.
In contrast to this, an alternative phase already shows insufficient separation at a lower loading level.
For the competitor’s product, loading amount of more than 0.1 mg was not possible because the enantiomeric excess of the 2nd peak was already less than 98%ee with a loading amount of 0.1 mg. The calculated maximum loading amount on CHIRAL ART Cellulose-SB of 1.6 mg was 10 times larger than that obtained for the competitor’s product due to the large differences in the peak shapes, even though the interval between repeat injections was higher!
| CHIRAL ART Cellulose-SB | CHIRALPAK® IB | |||
| 1st peak | 2nd peak | 1st peak | 2nd peak | |
| Enantiomeric excess | >99.9%ee | >99.3%ee | >99.9%ee | >97.9%ee |
| Recovery | 99% | 99% | 99% | 97% |
| Productivity (mg/h) | 3.1 | 3.3 | 0.3 | 0.3 |
Linear scale-up was performed using the appropriate scale-up factors. The Dynamic Axial Compression Column self-packed with CHIRAL ART Cellulose-SB 10 μm can be easily and linearly scaled-up for a greater purification scale. The final productivity is 366 and 390 mg/h respectively for peak 1 and 2.
| Analytical 250 x 4.6 mm ID | YMC-Actus Semi-preparative 250 x 20 mm ID | Self-packed DAC Preparative 250 x 50 mm ID | ||||
| 1st peak | 2nd peak | 1st peak | 2nd peak | 1st peak | 2nd peak | |
| Enantiomeric excess | >99.9%ee | >99.3%ee | >99.9%ee | >99.8%ee | >99.1%ee | >99.3%ee |
| Recovery | 99% | 99% | 97% | 99% | 99% | 94% |
| Productivity (mg/h) | 3.1 | 3.3 | 58.6 | 62.4 | 366 | 390 |
YMC Database
A selection of chiral applications can be found in our YMC database. You can search for chiral applications already known for your compounds.
Test Columns or Screening Kits
You can request a test column to initially test a chiral column before finally buy it if it works for your application. If the column is not suitable, simply return it without any further requirements.
Alternatively you can choose one of the YMC method development kits or request a customised screening kit with different CHIRAL ART phases. You only need to contact your local YMC contact for details.
FREE Chiral Screening Service
- >90% success rate
- Rapid screening within a short period of time
- Screening according to your requirements: e.g. RP-mode, MS-compatibility etc.
- Screening on all available CHIRAL ART phases
- Results presented in a detailed report
- Confidentiality Agreements can be arranged as necessary
Your YMC Success Rate
- Hit database: compiled from more than 600 samples supplied for contract service
- The 6 CHIRAL ART phases available so far can cover >90% of chiral separations
- About 95% of the LC applications are in NP/PO mode, while 5% are in RP mode
Method Development
- Method development based on phase screening
- According to your requirements
Preparative and Process Scale-Up
- Phase screening
- Preparative method development
- Small scale purification
Technical Library
| Title | Document Type | Language | Download |
 YMC Chiral Columns |
Brochure | EN | |
 CHIRAL ART Amylose-C Neo, Cellulose-C Prep Care and Use |
Care and Use Instructions | EN | |
| CHIRAL ART Amylose-SA, Cellulose-SB, Cellulose-SC, Cellulose-SJ Prep Care and Use |
Care and Use Instructions | EN | |
 YMC Bulk Packing Materials for RP-, NP- and Chiral Prep. LC |
Overview | EN | |
 Robust and efficient chiral purification |
Product Information | EN | |
 Linear Scale-Up in Preparative LC Method Development |
Technical Note | EN |
Please contact YMC for pricing or specific solutions for your purification process.
Julia Bartmann
Product Manager Bulk Media
ph. +49 2064 427-260
Particle Size | CHIRAL ART Amylose C-Neo | CHIRAL ART Cellulose-C | CHIRAL ART Amylose-SA | CHIRAL ART Cellulose-SB | CHIRAL ART Cellulose-SC | CHIRAL ART Cellulose-SJ |
| 10 µm | KBN99S11 | KCN99S11 | KSA99S11 | KSB99S11 | KSC99S11 | KSJ99S11 |
Typical pack sizes:
Laboratory scale: smallest amount is 100 grams up to 4 kg PE bottle
Industrial scale: more than 4 kg in double lined PE bags inside metal drums (10 or 25 kg drums)
