Peptides & Oligonucleotides

Joint Webinars
YMC & KNAUER

25th February 2025 - Free Participation

Case studies for a GLP-1 agonist and a peptide hormone

Method development and scale-up in peptide purification

Peptides have become one of the most important biopharmaceuticals. The high variability related to chain length and sequence of amino acids offers multiple pharmaceutical applications, and leads to specific demands regarding the production and purification.

This seminar therefore aims to provide the knowledge required for development of peptide purification methods based on case studies of up-to-date targets like a GLP-1 agonist and a peptide hormone.

Content

  • How to choose the ideal stationary phase: the most significant aspects to consider and the importance of extensive screening
  • What to consider for method development: finding efficient conditions by appropriate selection of solvents, pH and buffers
  • From overview to focused gradient: how to optimize a robust preparative method
  • Linear scale-up: Understanding the principle, system design and sample collection

Speakers:

  • Julia Bartmann, YMC Europe GmbH
  • Dr. Yannick Krauke, KNAUER Wissenschaftliche Geräte GmbH

When?

February, 25, 2025, 11:00 (CET)

Duration 1 hour

Applying AEX and IP-RP

Purification and quality control of oligonucleotides

Oligonucleotides are highly important biopharmaceuticals with strongly increasing relevance. Due to the high similarity of impurities originating from the synthesis, however, purification can be challenging.

This seminar demonstrates a successful large scale purification of an oligonucleotide using anion exchange chromatography (AEX) as well as efficient quality control by applying ion-pairing reversed phase chromatography (IP-RP).

Content

  • How to perform a large scale AEX purification: Design of preparative system and useful features
  • Benefits and limitations using AEX for preparative purification
  • What to consider for developing an IP-RP methods: selection of stationary phase, ion-pair reagent, and solvent conditions
  • How to improve analytical results by utilizing bioinert column hardware

Speakers:

  • Dr. Ulrike Krop, KNAUER Wissenschaftliche Geräte GmbH
  • Dr. Daniel Eßer, YMC Europe GmbH

When?

April, 1, 2025, 11:00 (CET)

Duration 1 hour

Who are these seminars for?

Advanced and beginners interested in peptides and/or oligonucleotides.

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You will receive the invitation to the online seminar room a few days before the event. Microsoft Teams will be used as the platform.

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