Molnupiravir (Lagevrio^®) is an antiviral medication to treat mild to medium COVID-19 infection. Molnupiravir is actually a prodrug of the active substrate N⁴-hydroxycytidine (NHC), a synthetic ribonucleoside analogue. The treatment leads to the introduction of copying errors during viral RNA replication and by this inhibits the viral reproduction.

This new Application Note demonstrates how molnupiravir and its active agent β-d-N⁴-hydroxycytidine can be separated by using a YMC-Triart C18 UHPLC column and a MS compatible mobile phase at pH 4.3 and relatively mild temperature of 40°C.

More information on YMC-Triart columns can be found on our new homepage or in the
YMC-Triart brochure.

The new YMC-Expertise-Portal is for HPLC experts such as you. The expertise area includes a large amount of valuable technical information that will make your everyday work easier. Whether for your laboratory work, for investigations or research and development – you will find the expert knowledge you need.

By registering for the expertise portal, you will gain exclusive access to:

• On-demand presentations with valuable content according to your individual schedule
• Useful online calculators for easy and convenient scale-up calculations
• Support documentation, including applications, white papers and much more

Convince yourself and register now here.

P. S.: Do you want to have a preview?
To give you an idea what you can expect, see YMC’s latest Technical Note on the optimisation of oligonucleotide analysis: YMC Tech Note - How to optimise your oligonucleotide analysis

 

 

YMC is looking forward to welcoming you to the 33^rd International Symposium on Chromatography in Budapest from 18^th till 22^nd September, 2022. It is one of the leading events for researchers in chromatography: A great opportunity for exchanging newest scientific insights and networking. Visit our booth and discuss with our technical specialists about new developments. Find out more about the conference and what to look forward to. See you in Budapest!

Meet us on September 21, 2022 at the LabSupply trade fair in Dresden! This regional lab trade fair offers comprehensive and specialist information about the latest technologies. This year's fair takes place in the International Congress Center. We look forward to informing you about news in (U)HPLC at our booth. Register now for your cost-free entry!