New Application Note: COVID-19 agent molnupiravir

Molnupiravir (Lagevrio®) is an antiviral medication to treat mild to medium COVID-19 infection. Molnupiravir is actually a prodrug of the active substrate N4-hydroxycytidine (NHC), a synthetic ribonucleoside analogue. The treatment leads to the introduction of copying errors during viral RNA replication and by this inhibits the viral reproduction.

This new Application Note demonstrates how molnupiravir and its active agent β-d-N4-hydroxycytidine can be separated by using a YMC-Triart C18 UHPLC column and a MS compatible mobile phase at pH 4.3 and relatively mild temperature of 40°C.

More information on YMC-Triart columns can be found on our new homepage or in the
YMC-Triart brochure.

Fig: Separation of molnupiravir and its active metabolite using a YMC-Triart C18 UHPLC column

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