The large variety of resins for downstream processing makes it very challenging to focus on the relevant criteria for selecting the best media for a specific process. Of course, efficiency and loadability are the most important ones. Therefore, these characteristics are evaluated during phase screening. But which factors additionally have to be considered for the development of an efficient process? One important aspect that can be easily overlooked is the backpressure that is caused by the packed bed. The lower the backpressure, the higher can be the flow rate and hence the resulting productivity is higher. Therefore, considering the pressure-flow-characteristics of the resin is very beneficial, as the impact of the backpressure on the overall productivity is so high.

This technical note shows a comparative study that investigates the pressure flow characteristics of a process scale YMC resin and an alternative resin. It is obvious that the differences can be very large. BioPro media from YMC exhibit very low backpressures as expected for a modern process resin. The applicable flow rate can be doubled with a consequential increase in productivity.

Are you lacking the time to pack your column?
Or do you have insufficient experience?
Here is the solution!
Rely on the experience of YMC and use prepacked glass columns. Our packing expertise is your advantage. You may choose from the following packing services for:

• new columns in standard and custom dimensions
  Depending on your required bed length, you can choose a column from our standard range. If you can’t find a suitable standard product, we will gladly discuss with you the possibility of a customized column.

• refilling of your used column
  Do you need to refill your existing YMC glass column? This service can be combined with maintenance of your glass column (e.g. changing of frits and pressure testing), if desired.
  
  
• stationary phases from YMC or from other suppliers
  Is your method restricted to the use of a specific stationary phase? Of course, we can pack your glass column according to your needs, using stationary phases manufactured either by YMC or by any other producer.

 

1. You provide us with your requirements regarding the column hardware, stationary phase, packing parameters (e.g. bed length) and column performance.
2. According to your needs, you will receive the corresponding quotation, including prices for column hardware, bulk material, consumables and work.
3. The packing process is carried out according to routine procedures. Subsequent column testing will confirm that the required column performance has been achieved. SOPs and our experience make sure that your column will be of the highest quality.
4. The column is released according to your specifications.
5. Packaging according to SOPs guarantees that your column will be shipped safely to your laboratory

You find all details summarised in our Packing Service Flyer.