The large variety of resins for downstream processing makes it very challenging to focus on the relevant criteria for selecting the best media for a specific process. Of course, efficiency and loadability are the most important ones. Therefore, these characteristics are evaluated during phase screening. But which factors additionally have to be considered for the development of an efficient process? One important aspect that can be easily overlooked is the backpressure that is caused by the packed bed. The lower the backpressure, the higher can be the flow rate and hence the resulting productivity is higher. Therefore, considering the pressure-flow-characteristics of the resin is very beneficial, as the impact of the backpressure on the overall productivity is so high.
This technical note shows a comparative study that investigates the pressure flow characteristics of a process scale YMC resin and an alternative resin. It is obvious that the differences can be very large. BioPro media from YMC exhibit very low backpressures as expected for a modern process resin. The applicable flow rate can be doubled with a consequential increase in productivity.