YMC i-Mail May 2023

Technical Note

Scalability of the BioPro IEX Resins

A major advantage of the YMC BioPro IEX resins is their full scalability. The elution order and retention times remain stable when using different particle sizes. This greatly facilitates up-scaling of downstream processes: process optimisation can be performed using analytical scale and then be transferred to production scale.
The identical chromatographic behaviour across the different particle sizes is shown for BioPro IEX S and BioPro IEX Q Resins. The appropriate particle size can be selected depending on the required resolution.

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BioPro IEX S
BioPro IEX Q Resins

Increased yield in oligonucleotide purification by continuous chromatography!

MCSGP is an interesting alternative for purifying mixtures of substances where cost-effectiveness is important. In classic batch chromatography, purity and yield often compete with each other. In MCSGP applications, both are achieved simultaneously. Therefore, highly efficient stationary phases like YMC-Triart Prep C8-S are the perfect choice.
This paper shows convincing performance data for demanding oligonucleotide purifications: The yield can be increased up to 91.6 % at 94.2% purity! This eliminates the need for renewed chromatography and the QA effort is significantly reduced.

Find more information about YMC-Triart Prep on the YMC homepage.
You can download the paper

Here

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