Method of choice: The combination of size exclusion chromatography (SEC) and light scattering detection (LS) determines molecular weight, especially for higher molecular species such as aggregates or oligomers. As an additional plus sample size and topology can also be revealed.
Special attention needs to be turned to the quality of SEC columns in order to provide signals unaffected by spikes. YMC’s SEC columns support LS-detection perfectly due to a high level of inertness, so that information of e.g., aggregation status, can be obtained.
Download the Technical Note to learn more about MALLS and its use with SEC.
In order to receive more information on YMC SEC columns visit our homepage or download our BioLC catalogue.