Polyethylene glycol (PEG) is a popular compound for modifying peptides, proteins, and other biologics through covalent-bond attachment for therapeutic drug applications. The analytical characterisation of PEGylated proteins can be a complex process, and many different methodologies are used.
In this new Whitepaper, created in cooperation with Ligand Pharmaceuticals Inc. (US), you will learn about:
- Challenges with analytical characterisation of PEGylated proteins
- Three current methodologies for charge-variant analysis using YMC’s BioPro IEX SF column
- Experimental results from the BioPro IEX SF column used to analyse PEGylated protein charge variants
For further information about YMC’s BioPro IEX columns, check out the IEX section of the YMC BioLC catalogue or visit our homepage.