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Fast UHPLC Analysis of SARS-CoV-2 drug Remdesivir and its active metabolite GS-441524

As the COVID-19 pandemic continues, the worldwide search for an effective treatment is still ongoing. Remdesivir and its active metabolite GS-441524 are both antiviral drugs that have been examined and partially approved for the treatment of COVID-19 due to their capability of inhibiting virus replication.

In this application note, the separation of GS-441524 and Remdesivir in only 3 minutes is shown. A YMC-Triart C18 UHPLC column provides fast and reliable results making it an ideal choice for QC purposes.

You can download the application note with the full method details here.

To get further information about the YMC-Triart series download the YMC-Triart brochure.

Improving the retention behaviour of hydrophilic compounds on polar stationary phases

Do you analyse hydrophilic compounds? Do you want to improve the retention on polar stationary phases such as PFP or Diol?

In this technical note, two different options for the improved analysis of hydrophilic compounds on YMC-Triart PFP and YMC-Triart Diol-HILIC are shown. The pH value and the amount of organic solvent are examined to learn more about the retention behaviour of basic, acidic and zwitterionic compounds using these phases. Due to their different selectivity, pentafluorophenyl (PFP) or Diol modifications are an ideal choice for the analysis of hydrophilic compounds which often remain unretained or unresolved on conventional C18 phases.

You can download the full method details here.

To get further information about the YMC-Triart series of columns download the YMC-Triart brochure.

Expert Tip: Column regeneration

Is your (U)HPLC column showing decreased performance?

Learn from experts how to regenerate (U)HPLC columns. Well suited washing procedures help to restore column performance. In addition, they prevent unwanted accumulation of contaminants on the stationary phase. However, there are a few things that have to be considered, e.g. type of cleaning solvent(s) and the volume needed for effective regeneration. For more details regarding column regeneration please download this helpful Expert Tip here.

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