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YMC
July 2020

Helpful overview of allowed changes in methods of the European Pharmacopoeia

 

Helpful overview of allowed changes in methods  of the European Pharmacopoeia  

Do you work with monographs from the European Pharmacopoeia (Ph. Eur.)?

Are you responsible for implementing methods from the Ph. Eur. into routine analysis?

Then you certainly know the situation very well: pharmacopoeia methods are rarely adapted to state-of-the-art. This can lead to issues with the quality of analysis results. Still in the European Pharmacopoeia changes in chromatographic methods are allowed to keep analysis up to date with new developments in technology. You just have to follow some clear guidelines. 

Take the first step into the direction of a problem-free routine analysis and download our helpful overview of allowed changes to methods in the Ph. Eur.

 

Expert tip: Column regeneration

 

A common reason for reduced column performance is unwanted adsorption of contaminants on the stationary phase. This may result in: 

  • increased back pressure 
  • altered retention times 
  • peak shape deformation.

If column performance has deteriorated by unwanted adsorption on the stationary phase, different cleaning steps can be applied to effectively regenerate the column. The cleaning conditions should be chosen in accordance with the characteristics of the impurities as well as the stability of the stationary phase. 
In this expert tip you will find general advice as well as three examples showing the efficiency of column regeneration for the three cases described above.

You can download your copy here.

Chromatogram before cleaning (top) and after cleaning (bottom); 1 = uracil, 2 = methyl benzoate, 3 = naphthalene.

Chromatogram before cleaning (top) and after cleaning (bottom); 1 = uracil, 2 = methyl benzoate, 3 = naphthalene.

 

 

Quick and easy HPLC method for cannabidiol and melatonin separation

 

YMC Europe: List of alternatives for BioLC columns!
Are you working with cannabinoids in medicinal products?

This application note describes how to obtain a fast separation of cannabidiol and melatonin which are compounds that can be used in medication for sleep disorders. 
Excellent peak shapes are achieved using YMC-Triart C18 in less than 7 min.

Get your copy of the application note now.

 

 

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