YMC i-Mail January 2025

Bioinert coated YMC Accura columns: Ideal for precise LC-MS analysis

YMC Accura columns are the solution for researchers working with challenging phosphate-rich molecules or metal-coordinating compounds. These bioinert columns feature an advanced inert coating, designed to prevent peak tailing and carry-over, while delivering optimal recovery rates.

Their seamless compatibility with MS detectors, as demonstrated in this technical note, ensures enhanced workflow accuracy, making them an indispensable tool for high-sensitivity applications.

Optimise your LC-MS results with YMC Accura columns today!

Discover their performance — read the technical note for details.

Achieve excellent native IEX-MS with YMC Accura BioPro IEX SF

Featuring bioinert coated hardware and a compact 2.1 mm inner diameter, this column ensures sharper peaks, superior resolution, and reliable performance under native, MS-compatible ion exchange (IEX) conditions.

 

Proven Performance:

  • Trusted by Roche for advanced mAb workflows
  • Minimises artefacts for cleaner data
  • Consistent, high-resolution results for cutting-edge biopharmaceutical analysis

 

Elevate your biopharmaceutical processes with YMC Accura BioPro IEX SF—simplified workflows and precision-driven results.

 

Download the Application Note for more details.

Precise DAR analysis of a 3rd generation ADC

Achieve unparalleled separation efficiency of a site-specific antibody-drug-conjugate (ADC) with the YMC-Triart Bio C4 column. This advanced reversed-phase (RP) column features robust organic/inorganic hybrid silica particles with a 300 Å pore size, optimised for biopharmaceutical separations.

Key Features:

  • Balanced hydrophobicity: The butyl (C4) functionalisation provides optimal hydrophobic interactions, essential for precise drug-to-antibody ratio (DAR) determinations.
  • High temperature stability: Engineered to withstand temperatures up to 90°C, facilitating the separation of large biomolecules, including intact antibodies and ADCs.
  • LC-MS compatibility: Delivers excellent peak shapes with mobile phases containing formic acid, enhancing sensitivity in mass spectrometry workflows.