The development of a preparative process typically consists of three steps:
➔ Method development at analytical scale
➔ Loadability studies
➔ Final scale-up to the preparative process
To perform this process development as smoothly as possible the use of fully scalable particles is very important. Together with one of the leading global pharmaceutical companies, the scalability of the YMC-Triart material has been tested with an IP-RP oligonucleotide separation.
The results showed that
➔ An easy method development was possible due to full scalability of YMC-Triart
➔ Comparable yield and purity could be obtained with three particle sizes
➔ YMC-Triart C18 shows an excellent selectivity for oligonucleotide separations
Download your copy of the new application note.