This compact guide summarises all the important aspects for the precise separation of protected and unprotected single-stranded DNA oligonucleotides. You have a clear overview of all the essentials:

1. Proven strategies for high resolution and sensitivity.
2. Information on the selection of the appropriate ion pairing agent.
3. Influence of column hardware and temperature.

A teaser in advance: The new bioinert-coated YMC Accura Triart C18 column is also an absolute gain for your analysis.
You can download the Technical Note below to unlock your full potential.

For further oligonucleotide applications look homepage or download the YMC Oligonucleotide Columns brochure.

The new YMC Accura BioPro IEX columns ensure exceptionally high recoveries. They are the ideal choice for challenging analyses of:

• Oligonucleotides and nucleotides,
• Antibodies,
• Proteins and peptides.

Your benefits from using YMC Accura BioPro IEX columns:
The columns provide very sharp peaks with high sensitivities due to an efficient bioinert surface coating of the column body and frits. YMC Accura BioPro IEX columns are the 1^st choice for high resolution analysis of oligonucleotides, antibodies, and proteins – especially when coupled with mass spectrometry.

Their non-porous hydrophilic polymer beads enable high efficiencies and high throughput analyses. The superior lot-to-lot reproducibility guarantees highly reliable results.

Get to know more about the bioinert IEX columns on our dedicated YMC Accura BioPro IEX website or check out the brand new flyer.