Mass spectrometric analysis of monoclonal antibodies

Lars M. H. Reinders from the Institute for Energy and Environmental Technology e.V. (IUTA) presents in this online presentation the mass spectrometric analysis of monoclonal antibodies. He discusses one-dimensional as well as two-dimensional approaches. The presentation starts with one-dimensional antibody analysis. The special features of intact proteins and peptides are the focus here. The presentation continues with multidimensional antibody analytics. The application possibilities of two-dimensional antibody analytics are clearly presented and the following questions are clarified: Which modes are there? When is which mode used? Subsequently, alternative uses of 2D-HPLC-MS are considered, i.e. the diverse automation possibilities.

Lars M. H. Reinders graduated in Applied Chemistry with a focus on Instrumental Analytics from Niederrhein University of Applied Sciences in 2017. He then began his doctorate at the Faculty of Chemistry at the Chair of "Instrumental Analytical Chemistry" at the University of Duisburg-Essen. His research focuses on the development and validation of analytical methods for the quantification and identification of monoclonal antibodies. Since 2017, he has been working as a research associate at the Institute for Energy and Environment e. V. in the area of Research Analytics & Miniaturisation.