In this online presentation, Dr Björn Fischer from the Institute of Pharmaceutical Technology & Biopharmacy at Heinrich Heine University Düsseldorf gives detailed insights into new spectroscopic developments, especially with regard to coupling with liquid chromatography. The first part of the presentation deals with fluorescence spectroscopy. Here, among other things, the development of a fluorescence detector along an application is presented. In the second part, Raman spectroscopy is discussed and the new developments in this field are shown.