Ion Exchange Resins
Ion exchange media are widely used in the purification of biomolecules. For instance, in industrial-scale protein production processes, IEX media are often used for initial product capture and intermediate purification stages as well as the final polishing steps. This separation technique offers several advantages in comparison to other chromatographic methods, e.g. high capacity and fast throughput.
BioPro IEX and BioPro IEX SmartSep form a series of ion exchange resins specifically designed for biochromatography. They are available as a strong anion exchanger (BioPro IEX Q) and a strong cation exchanger (BioPro IEX S).
The media are based on a hydrophilic polymer matrix, with a particle size of 10 µm, 20 µm, 30 µm and 75 µm. BioPro IEX offers a high dynamic binding capacity (DBC), together with low non-specific adsorption and excellent recovery. BioPro IEX is manufactured in lot sizes up to 450 L.

Advantages
- Excellent dynamic binding capacity
- Low non-specific adsorption and high recovery
- High capacity even at high flow rates
- Full compliances with GMP requirements
- Increased productivity
- Reduced processing costs
Available Ion Exchange Resins:
AEX Resins
CEX Resins
BioPro IEX SmartSep Q10 | BioPro IEX SmartSep Q20 | BioPro IEX SmartSep Q30 | BioPro IEX Q75 | |
Ion Exchange Type | strong anion exchanger | |||
Charged Group | -R-N+(CH3)3 | |||
Base Material | hydrophilic polymer beads | |||
Particle Size [µm] | 10 | 20 | 30 | 75 |
pH Range | 2.0 - 12.0 (compatible with 1 M NaOH for CIP) | |||
Ion Exchange Capacity [meq/mL resin] | min. 0.08 | min. 0.08 | min. 0.08 | min. 0.10 |
Dynamic Binding Capacity [mg/mL resin] | min. 110 (BSA) | min. 110 (BSA) | min. 110 (BSA) | min. 160 (BSA) |
Compression Factor | 1.05-1.15 | |||
Typical Flow Rate | 200-1000 cm/h, max. 2000 cm/h | |||
Pressure Limit | 4 MPa | 3 MPa | 3 MPa | 0.3 MPa |
BioPro IEX SmartSep S10 | BioPro IEX SmartSep S20 | BioPro IEX SmartSep S30 | BioPro IEX S75 | |
Ion Exchange Type | strong cation exchanger | |||
Charged Group | -R-SO3- | |||
Base Material | hydrophilic polymer beads | |||
Particle Size [µm] | 10 | 20 | 30 | 75 |
pH Range | 2.0 - 12.0 (compatible with 1 M NaOH for CIP) | |||
Ion Exchange Capacity [meq/mL resin] | min. 0.08 | min. 0.08 | min. 0.08 | min. 0.10 |
Dynamic Binding Capacity [mg/mL resin] | min. 110 (Lysozyme) | min. 110 (Lysozyme) | min. 110 (Lysozyme) | min. 160 (Lysozyme) |
Compression Factor | 1.05-1.15 | |||
Typical Flow Rate | 200-1000 cm/h, max. 2000 cm/h | |||
Pressure Limit | 4 MPa | 3 MPa | 3 MPa | 0.3 MPa |
Multiple Sample Options Available!

High sample loading at high flow rates is determined by the dynamic binding capacity of an ion exchange resin. The dynamic binding capacity of BioPro is excellent even at high flow rates. When compared to similar competitor products it consistently exhibits a higher dynamic binding capacity. This results in higher sample loading in preparative processes.




IgY is a commonly used immunoglobulin from egg yolk. In contrast to human IgG-antibodies, IgY does not bind to Protein A which makes the preparative purification of these molecules challenging. This application shows the successful two-step purification of IgY using IEX as an efficient capturing step.
Title | Document Type | Language | Download |
Application Note | EN | ||
Application Note | EN | ||
Brochure | EN | ||
Brochure | EN | ||
Care and Use Instructions | EN | ||
Care and Use Instructions | EN | ||
Care and Use Instructions | EN | ||
Flyer | EN | ||
Overview | DE | ||
Overview | EN | ||
Overview | EN | ||
Poster | EN | ||
Product Information | EN | ||
Product Information | DE | ||
Technical Note | EN | ||
Technical Note | EN | ||
Technical Note | EN | ||
Technical Note | E | ||
Technical Note | EN | ||
Technical Note | EN | ||
Technical Note | EN | ||
Whitepaper | EN | ||
Whitepaper | DE |

Please contact YMC for pricing or specific solutions for your purification process.
Julia Bartmann
Product Manager Bulk Media
ph. +49 2064 427-260
Product | Particle Size | Product Code |
BioPro IEX SmartSep Q10 | 10 µm | QSA0S10 |
BioPro IEX SmartSep Q20 | 20 µm | QSA0S20 |
BioPro IEX SmartSep Q30 | 30 µm | QSA0S30 |
BioPro IEX Q75 | 75 µm | QAA0S75 |
BioPro IEX SmartSep S10 | 10 µm | SSA0S10 |
BioPro IEX SmartSep S20 | 20 µm | SSA0S20 |
BioPro IEX SmartSep S30 | 30 µm | SSA0S30 |
BioPro IEX S75 | 75 µm | SPA0S75 |
Typical pack sizes:
50 mL, 250 mL, 1 L, 5L, 10 L, 20 L
Larger or customised pack sizes are available on request.
Regulatory support file under non-disclosure agreement. Used in validated cGMP-manufacturing processes. Customised material available on request. DMF registered with FDA.
Multiple Sample Options Available!
