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Guide to SFC Columns for Supercritical Fluid Chromatography

What Are SFC Columns?

SFC Columns (Supercritical Fluid Chromatography Columns) are specifically designed for use with supercritical carbon dioxide as the mobile phase. This technique, known as supercritical fluid chromatography (SFC), combines the benefits of gas and liquid chromatography and is especially valued for its speed, efficiency, and eco-friendly solvent use. YMC’s SFC columns are available in both chiral and achiral phases, offering maximum flexibility for analytical and preparative applications.

How Does SFC Chromatography Work?

SFC chromatography uses supercritical CO₂, which has lower viscosity and higher diffusivity compared to traditional liquid mobile phases. This results in faster separations—often 3 to 5 times quicker than with conventional HPLC. SFC is particularly useful for thermally labile or complex compounds, enabling improved resolution and reduced solvent consumption. YMC SFC Columns are optimized for chiral separations, making them a valuable tool in the pharmaceutical and chemical industries.

Advantages of YMC SFC Columns

YMC’s SFC Columns offer numerous advantages for both analytical and preparative supercritical fluid chromatography. They deliver high separation efficiency and excellent peak symmetry, even at high flow rates. Their exceptional reproducibility ensures consistent results across batches and long-term usage. Thanks to the use of supercritical CO₂ as the primary mobile phase, YMC’s SFC solutions are considered an environmentally friendly alternative to conventional normal-phase HPLC, reducing solvent consumption and waste. In addition, the broad selection of chemistries and scalable formats allows for flexible method development and seamless transfer from lab to production.

Applications of SFC Columns

YMC SFC Columns are used across a wide range of industries, including:

  • Pharmaceutical research and development

  • Chiral separations in enantiomeric purity testing

  • Natural product purification

  • Preparative chromatography for scalable purification workflows

 

Need expert support for selecting the right SFC column for your method? Contact YMC Europe for personalized advice and technical guidance.

Contact us for consultation
  • YMC Europe GmbH
  • Phone +49 2064 427-0
  • Schöttmannshof 19
  • Fax +49 2064 427-222
  • D-46539 Dinslaken