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Reliable quality control

Purity analysis of peptide-oligonucleotide conjugates

This Application Note introduces an optimised IP-RP method that ensures high resolution and reproducibility in the analysis of a model POC. Using a bioinert wide pore YMC Accura Triart Bio C18 column provides excellent peak resolution and full separation of modified and unmodified oligonucleotides.

Download the Application Note for full details and strengthen your analytical workflow.

New gold standard for oligonucleotide analysis with IP-RP

YMC Accura Triart Bio C18 columns are ideal for oligonucleotide analysis. They ensure high reproducibility, efficient separation and stable performance. These columns are practical for method development: all possible modifiers and ion pairing agents can be used flexibly, while consistently achieving stable results. They are ideally combined with the corresponding bioinert guard cartridges.

Find full method details in the Product Information based on the publication by the Vrije Universiteit Brussel.

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Sitting down with Stefanie Rubenzucker

Stefanie Rubenzucker, pre-doctoral researcher at the University of Vienna’s Department of Analytical Chemistry, spoke with SelectScience about her work in bioactive lipid analysis. The chemical diversity, isomeric separations, and working with limited sample volumes pose some challenges in lipidomics.

Her innovative LC-MS/MS method using the bioinert YMC Accura Triart C18 now enables the detection of 388 lipids in just 20 minutes with exceptional sensitivity and reproducibility

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